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In adult patints without clinically vidnt CHD, but with multipl isk actos CHD such as ag, smoking, hyptnsion, low HDL-C, a amily histoy aly CHD, atovastatin is indicatd to.
Atovastatin is a slctiv, comptitiv inhibit3-hydoxy-3-mthylglutayl-conzym A (HMG-CoA) ductas, th at-limiting nzym that convts 3-HMG-CoA tmvalonat, a pcusstols, including cholstol. Cholstol and tiglycids (TG) ciculat in th bloodstam as pat lipopotin complxs. With ultacntiugation, ths complxs spaat inthigh-dnsity lipopotin (HDL), intmdiat-dnsity lipopotin (IDL), low-dnsity lipopotin (LDL) and vy-low-dnsity lipopotin (VLDL) actions. TG and cholstol in th liv a incopoatd intVLDL and lasd intth plasma dlivy tpiphal tissus. LDL is omd om VLDL and is catabolizd pimaily though th high-ainity LDL cpto.
Hpain: In a clinical study conductd in halthy subjcts, clopidogl did not ncssitat modiication th hpain dos alt th ct hpain on coagulation. Co-administation hpain had nct on th inhibition platlt agggation inducd by clopidogl. A phamacodynamic intaction btwn clopidogl and hpain is possibl, lading tincasd isk blding. Tho, concomitant us should b undtakn with caution.
ATOLIP CV (atovastatin and clopidogl) is indicatd in patints whom tatmnt with both atovastatin and clopidogl is appopiat.
Oth ibats: Bcaus it is known that th isk myopathy duing tatmnt with HMG-CoA ductas inhibitos is incasd with concunt administation oth ibats, ATOLIP CV should b administd with caution whn usd concomitantly with oth ibats.
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